Which SNRI is indicated for generalized anxiety disorder and major depressive disorder?

Which SNRI is indicated for generalized anxiety disorder and major depressive disorder?

• A. Duloxetine (Cymbalta)
• B. Sertraline (Zoloft)
• C. Fluoxetine (Prozac)
• D. Paroxetine (Paxil)

Answer: (A)

Duloxetine, marketed under the brand name Cymbalta, is an SNRI (serotonin-norepinephrine reuptake inhibitor) that is indicated for both generalized anxiety disorder (GAD) and major depressive disorder (MDD). Its mechanism of action involves the inhibition of the reuptake of serotonin and norepinephrine, neurotransmitters that are critical in mood regulation and anxiety. Because of this dual action, Duloxetine helps alleviate symptoms associated with both anxiety and depression, making it a versatile treatment option. In contrast, while medications such as Sertraline, Fluoxetine, and Paroxetine are effective for major depressive disorder, they belong to the class of SSRIs (selective serotonin reuptake inhibitors) and may not have the same level of efficacy or approval specifically for generalized anxiety disorder as Duloxetine does. While some SSRIs can also be used to treat GAD, Duloxetine's specific indication for both disorders underscores its clinical relevance in treating patients who experience comorbid anxiety and depression.

Duloxetine, marketed under the brand name Cymbalta, is an SNRI (serotonin-norepinephrine reuptake inhibitor) that is indicated for both generalized anxiety disorder (GAD) and major depressive disorder (MDD). Its mechanism of action involves the inhibition of the reuptake of serotonin and norepinephrine, neurotransmitters that are critical in mood regulation and anxiety. Because of this dual action, Duloxetine helps alleviate symptoms associated with both anxiety and depression, making it a versatile treatment option.

In contrast, while medications such as Sertraline, Fluoxetine, and Paroxetine are effective for major depressive disorder, they belong to the class of SSRIs (selective serotonin reuptake inhibitors) and may not have the same level of efficacy or approval specifically for generalized anxiety disorder as Duloxetine does. While some SSRIs can also be used to treat GAD, Duloxetine's specific indication for both disorders underscores its clinical relevance in treating patients who experience comorbid anxiety and depression.